Version 5.4
Homo sapiens Gene: STIP1
Summary
InnateDB Gene IDBG-53106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STIP1
Gene Name stress-induced-phosphoprotein 1
Synonyms HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1; STI1L
Species Homo sapiens
Ensembl Gene ENSG00000168439
Encoded Proteins
IDBP-53108
stress-induced-phosphoprotein 1
IDBP-53110
stress-induced-phosphoprotein 1
IDBP-597435
stress-induced-phosphoprotein 1
IDBP-597817
stress-induced-phosphoprotein 1
IDBP-594356
stress-induced-phosphoprotein 1
IDBP-593870
stress-induced-phosphoprotein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64185272-64204543
Strand Forward strand
Band q13.1
Transcripts
ENST00000358794 ENSP00000351646
ENST00000305218 ENSP00000305958
ENST00000355603
ENST00000536973 ENSP00000441036
ENST00000538945 ENSP00000445957
ENST00000543847 ENSP00000442704
ENST00000540736
ENST00000540501
ENST00000544739
ENST00000537479
ENST00000538497
ENST00000540887 ENSP00000443416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 106 [view]
Protein-Protein 106 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006950 response to stress
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024966
View Gene Order
ENSBTAG00000015663
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05020
Prion diseases pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.337295 Hs.618350 Hs.702077
RefSeq NM_001282652 NM_001282653 NM_006819
HUGO
OMIM
CCDS CCDS60827 CCDS60828 CCDS8058
HPRD 05454
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca