|Homo sapiens Gene: STIP1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||stress-induced-phosphoprotein 1|
|Synonyms||HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1; STI1L;|
|Useful resources||Stemformatics EHFPI ImmGen|
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
|Genomic Location||Chromosome 11:64185272-64204543|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Prion diseases pathway
|UniProt Splice Variant|
|UniGene||Hs.337295 Hs.618350 Hs.702077|
|RefSeq||NM_001282652 NM_001282653 NM_006819|
|CCDS||CCDS60827 CCDS60828 CCDS8058|
|RNA Seq Atlas|