Homo sapiens Gene: UPF2
Summary
InnateDB Gene IDBG-53271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPF2
Gene Name UPF2 regulator of nonsense transcripts homolog (yeast)
Synonyms HUPF2; RENT2; smg-3;
Species Homo sapiens
Ensembl Gene ENSG00000151461
Encoded Proteins
UPF2 regulator of nonsense transcripts homolog (yeast)
UPF2 regulator of nonsense transcripts homolog (yeast)
UPF2 regulator of nonsense transcripts homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:11920022-12043170
Strand Reverse strand
Band p14
Transcripts
ENST00000357604 ENSP00000350221
ENST00000356352 ENSP00000348708
ENST00000397053 ENSP00000380244
ENST00000460569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
Experimentally validated
Total 111 [view]
Protein-Protein 111 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001889 liver development
GO:0006406 mRNA export from nucleus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031100 organ regeneration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0035145 exon-exon junction complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Gene Expression pathway
KEGG
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370689 Hs.597381 Hs.610110 Hs.732383
RefSeq NM_015542 NM_080599
HUGO
OMIM
CCDS CCDS7086
HPRD 10405
IMGT
EMBL
GenPept
RNA Seq Atlas