Homo sapiens Gene: VEGFB
Summary
InnateDB Gene IDBG-53284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEGFB
Gene Name vascular endothelial growth factor B
Synonyms VEGFL; VRF;
Species Homo sapiens
Ensembl Gene ENSG00000173511
Encoded Proteins
vascular endothelial growth factor B
vascular endothelial growth factor B
vascular endothelial growth factor B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64234538-64238793
Strand Forward strand
Band q13.1
Transcripts
ENST00000309422 ENSP00000311127
ENST00000426086 ENSP00000401550
ENST00000543462
ENST00000541681 ENSP00000442526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
GO:0042803 protein homodimerization activity
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002576 platelet degranulation
GO:0006493 protein O-linked glycosylation
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0010629 negative regulation of gene expression
GO:0030168 platelet activation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035470 positive regulation of vascular wound healing
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060048 cardiac muscle contraction
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060976 coronary vasculature development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0016020 membrane
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Response to elevated platelet cytosolic Ca2+ pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pathways in cancer pathway
INOH
GPCR signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
VEGF and VEGFR signaling network
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.732095 Hs.78781
RefSeq NM_001243733 NM_003377
HUGO
OMIM
CCDS CCDS58144 CCDS8062
HPRD 03237
IMGT
EMBL
GenPept
RNA Seq Atlas