InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VEGFB

Summary

InnateDB Gene

IDBG-53284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VEGFB

Gene Name

vascular endothelial growth factor B

Synonyms

VEGFL; VRF

Species

Homo sapiens

Ensembl Gene

ENSG00000173511

Encoded Proteins

IDBP-53288

vascular endothelial growth factor B

IDBP-377095

vascular endothelial growth factor B

IDBP-586212

vascular endothelial growth factor B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:64234538-64238793

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000309422	ENSP00000311127
ENST00000426086	ENSP00000401550
ENST00000543462
ENST00000541681	ENSP00000442526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity
GO:0042803	protein homodimerization activity
GO:0043183	vascular endothelial growth factor receptor 1 binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002576	platelet degranulation
GO:0006493	protein O-linked glycosylation
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0010629	negative regulation of gene expression
GO:0030168	platelet activation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035470	positive regulation of vascular wound healing
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060048	cardiac muscle contraction
GO:0060754	positive regulation of mast cell chemotaxis
GO:0060976	coronary vasculature development
GO:0070374	positive regulation of ERK1 and ERK2 cascade