Version 5.4
Homo sapiens Gene: PDGFRB
Summary
InnateDB Gene IDBG-53326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFRB
Gene Name platelet-derived growth factor receptor, beta polypeptide
Synonyms CD140B; IBGC4; IMF1; JTK12; PDGFR; PDGFR-1; PDGFR1
Species Homo sapiens
Ensembl Gene ENSG00000113721
Encoded Proteins
IDBP-53328
platelet-derived growth factor receptor, beta polypeptide
IDBP-473797
platelet-derived growth factor receptor, beta polypeptide
IDBP-481511
platelet-derived growth factor receptor, beta polypeptide
IDBP-478900
platelet-derived growth factor receptor, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150113837-150155872
Strand Reverse strand
Band q32
Transcripts
ENST00000261799 ENSP00000261799
ENST00000520851
ENST00000520579 ENSP00000430026
ENST00000519575
ENST00000521723
ENST00000520229
ENST00000522466
ENST00000517488 ENSP00000429218
ENST00000517957 ENSP00000430715
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 124 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0004992 platelet activating factor receptor activity
GO:0005017 platelet-derived growth factor-activated receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005102 receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0038085 vascular endothelial growth factor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001894 tissue homeostasis
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006468 protein phosphorylation
GO:0006807 nitrogen compound metabolic process
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009636 response to toxic substance
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 response to organic cyclic compound
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0032355 response to estradiol
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032526 response to retinoic acid
GO:0032956 regulation of actin cytoskeleton organization
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033993 response to lipid
GO:0034405 response to fluid shear stress
GO:0035441 cell migration involved in vasculogenesis
GO:0035556 intracellular signal transduction
GO:0035789 metanephric mesenchymal cell migration
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035909 aorta morphogenesis
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042542 response to hydrogen peroxide
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045087 innate immune response
GO:0045840 positive regulation of mitosis
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048705 skeletal system morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048839 inner ear development
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050921 positive regulation of chemotaxis
GO:0055003 cardiac myofibril assembly
GO:0055093 response to hyperoxia
GO:0060326 cell chemotaxis
GO:0060981 cell migration involved in coronary angiogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071670 smooth muscle cell chemotaxis
GO:0072075 metanephric mesenchyme development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072275 metanephric glomerulus morphogenesis
GO:0072277 metanephric glomerular capillary formation
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0090280 positive regulation of calcium ion import
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0031226 intrinsic component of plasma membrane
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024620
View Gene Order
ENSBTAG00000002804
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04540
Gap junction pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04020
Calcium signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
s1p_s1p1_pathway
S1P1 pathway
ptp1bpathway
Signaling events mediated by PTP1B
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
nectin_pathway
Nectin adhesion pathway
myc_represspathway
Validated targets of C-MYC transcriptional repression
tcptp_pathway
Signaling events mediated by TCPTP
s1p_s1p3_pathway
S1P3 pathway
shp2_pathway
SHP2 signaling
pdgf_pathway
PDGF receptor signaling network
integrin3_pathway
Beta3 integrin cell surface interactions
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL E5RJ14
UniProt Splice Variant
Entrez Gene 5159
UniGene Hs.509067
RefSeq NM_002609 XM_005268464
HUGO HGNC:8804
OMIM 173410
CCDS CCDS4303
HPRD 01423
IMGT
EMBL AC005895 AC011382
GenPept
RNA Seq Atlas 5159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca