Homo sapiens Gene: CAMK2A | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-53452.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CAMK2A | ||||||||||||||||||||||
Gene Name | calcium/calmodulin-dependent protein kinase II alpha | ||||||||||||||||||||||
Synonyms | CAMKA | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000070808 | ||||||||||||||||||||||
Encoded Proteins |
calcium/calmodulin-dependent protein kinase II alpha
calcium/calmodulin-dependent protein kinase II alpha
calcium/calmodulin-dependent protein kinase II alpha
calcium/calmodulin-dependent protein kinase II alpha
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
CAMK2A promotes TLR-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating MAP3K7 and IRF3 in macrophages. (Demonstrated in murine model)
|
||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Camk2a promotes Tlr-triggered pro-inflammatory cytokine and type-I-IFN production by directly binding and activating Map3k7 and Irf3 in mouse macrophages.
|
||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:150219491-150290291 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q32 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TGF_beta_Receptor pathway
|
||||||||||||||||||||||
REACTOME |
Interferon gamma signaling pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Trafficking of AMPA receptors pathway
Cellular responses to stress pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Interferon Signaling pathway
Post NMDA receptor activation events pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
|
||||||||||||||||||||||
KEGG |
GnRH signaling pathway pathway
Wnt signaling pathway pathway
Olfactory transduction pathway
ErbB signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
|
||||||||||||||||||||||
INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||
PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
Netrin-mediated signaling events
FGF signaling pathway
TGF-beta receptor signaling
Noncanonical Wnt signaling pathway
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_015981 NM_171825 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS43386 CCDS43387 | ||||||||||||||||||||||
HPRD | 06532 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||