Homo sapiens Gene: IGF1
Summary
InnateDB Gene IDBG-53609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF1
Gene Name insulin-like growth factor 1 (somatomedin C)
Synonyms IGF-I; IGF1A; IGFI;
Species Homo sapiens
Ensembl Gene ENSG00000017427
Encoded Proteins
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor 1 (somatomedin C)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IGF1 is a PI3K-activating ligand that increases the secretion of IL6 and TNF in lipopolysaccharide (LPS)-stimulated mast cells, as well as attenuating the production of IL1B. (Demonstrated in murine model)
IGF1 induces HIF1A-TLR9 cross talk that regulates inflammatory responses in glioma cells and this regulation functions in both positive and negative feedback loops.
IGF1 suppresses the expression of TLR4 to exert an anti-inflammatory effect of exercising. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Igf11 is a PI3K-activating ligand that increases the secretion of Il6 and Tnf in lipopolysaccharide (LPS)-stimulated mast cells, as well as attenuating the production of Il1b.
[Mus musculus] Igf1 induces Hif1a-Tlr9 cross talk that regulates inflammatory responses in glioma cells and this regulation functions in both positive and negative feedback loops. (Demonstrated in human)
[Mus musculus] Igf1 suppresses the expression of Tlr4 to exert an anti-inflammatory effect of exercising.
Entrez Gene
Summary The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:102395867-102480645
Strand Reverse strand
Band q23.2
Transcripts
ENST00000337514 ENSP00000337612
ENST00000307046 ENSP00000302665
ENST00000392905 ENSP00000376638
ENST00000392904 ENSP00000376637
ENST00000456098 ENSP00000394999
ENST00000424202 ENSP00000416811
ENST00000481539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001501 skeletal system development
GO:0001775 cell activation
GO:0001932 regulation of protein phosphorylation
GO:0001974 blood vessel remodeling
GO:0002576 platelet degranulation
GO:0006260 DNA replication
GO:0006928 cellular component movement
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0007517 muscle organ development
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009441 glycolate metabolic process
GO:0010001 glial cell differentiation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896 muscle hypertrophy
GO:0014904 myotube cell development
GO:0014911 positive regulation of smooth muscle cell migration
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030104 water homeostasis
GO:0030166 proteoglycan biosynthetic process
GO:0030168 platelet activation
GO:0030324 lung development
GO:0030879 mammary gland development
GO:0031017 exocrine pancreas development
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035264 multicellular organism growth
GO:0035630 bone mineralization involved in bone maturation
GO:0040014 regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 negative regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045445 myoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045740 positive regulation of DNA replication
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048286 lung alveolus development
GO:0048468 cell development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048839 inner ear development
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051246 regulation of protein metabolic process
GO:0051450 myoblast proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060426 lung vasculature development
GO:0060463 lung lobe morphogenesis
GO:0060509 Type I pneumocyte differentiation
GO:0060510 Type II pneumocyte differentiation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736 prostate gland growth
GO:0060740 prostate gland epithelium morphogenesis
GO:0060741 prostate gland stromal morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000288 positive regulation of myoblast proliferation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016942 insulin-like growth factor binding protein complex
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
SHC-related events triggered by IGF1R pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Metabolism of proteins pathway
Response to elevated platelet cytosolic Ca2+ pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Peptide hormone metabolism pathway
Hemostasis pathway
KEGG
Oocyte meiosis pathway
p53 signaling pathway pathway
mTOR signaling pathway pathway
Focal adhesion pathway
Long-term depression pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Pathways in cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
INOH
IGF1 signaling pathway pathway
GPCR signaling pathway
PID BIOCARTA
Nfat and hypertrophy of the heart [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.160562 Hs.604258 Hs.624759 Hs.708628
RefSeq NM_000618 NM_001111283 NM_001111284 NM_001111285 XM_005268835
HUGO
OMIM
CCDS CCDS44960 CCDS44961 CCDS44962 CCDS9091
HPRD 00936
IMGT
EMBL
GenPept
RNA Seq Atlas