Homo sapiens Gene: GPX3
Summary
InnateDB Gene IDBG-54044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX3
Gene Name glutathione peroxidase 3 (plasma)
Synonyms GPx-P; GSHPx-3; GSHPx-P;
Species Homo sapiens
Ensembl Gene ENSG00000211445
Encoded Proteins
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
glutathione peroxidase 3 (plasma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:151020438-151028993
Strand Forward strand
Band q33.1
Transcripts
ENST00000388825 ENSP00000373477
ENST00000521722
ENST00000521650 ENSP00000427873
ENST00000519214 ENSP00000430508
ENST00000517973 ENSP00000429709
ENST00000521632 ENSP00000430743
ENST00000520597
ENST00000520059 ENSP00000429314
ENST00000625178
ENST00000622181 ENSP00000484258
ENST00000614343 ENSP00000483660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0008134 transcription factor binding
GO:0008430 selenium binding
Biological Process
GO:0006979 response to oxidative stress
GO:0006982 response to lipid hydroperoxide
GO:0042744 hydrogen peroxide catabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
KEGG
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2878
UniGene Hs.725787
RefSeq NM_002084
HUGO HGNC:4555
OMIM 138321
CCDS CCDS43389
HPRD 11750
IMGT
EMBL
GenPept
RNA Seq Atlas 2878