Homo sapiens Gene: FZD2
Summary
InnateDB Gene IDBG-54110.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD2
Gene Name frizzled family receptor 2
Synonyms fz-2; Fz2; fzE2; hFz2;
Species Homo sapiens
Ensembl Gene ENSG00000180340
Encoded Proteins
frizzled family receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:44557459-44559570
Strand Forward strand
Band q21.31
Transcripts
ENST00000315323 ENSP00000323901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001944 vasculature development
GO:0003149 membranous septum morphogenesis
GO:0003150 muscular septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0007166 cell surface receptor signaling pathway
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267 cell-cell signaling
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0007608 sensory perception of smell
GO:0008406 gonad development
GO:0030182 neuron differentiation
GO:0030825 positive regulation of cGMP metabolic process
GO:0030855 epithelial cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022 hard palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060119 inner ear receptor cell development
GO:0060412 ventricular septum morphogenesis
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032589 neuron projection membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
Ca2+ pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
GPCR ligand binding pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Wnt signaling network
Noncanonical Wnt signaling pathway
Cross-References
SwissProt Q14332
TrEMBL Q86UZ8
UniProt Splice Variant
Entrez Gene 2535
UniGene Hs.142912 Hs.626366
RefSeq NM_001466
HUGO HGNC:4040
OMIM 600667
CCDS CCDS11484
HPRD
IMGT
EMBL AB017364 BC052266 BC113402 BC113404 L37882
GenPept AAB46397 AAH52266 AAI13403 AAI13405 BAA34667
RNA Seq Atlas 2535