InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD2

Summary

InnateDB Gene

IDBG-54110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD2

Gene Name

frizzled family receptor 2

Synonyms

fz-2; Fz2; fzE2; hFz2

Species

Homo sapiens

Ensembl Gene

ENSG00000180340

Encoded Proteins

IDBP-54112

frizzled family receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44557459-44559570

Strand

Forward strand

Band

q21.31

Transcripts

ENST00000315323

ENSP00000323901

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267	cell-cell signaling
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0007608	sensory perception of smell
GO:0008406	gonad development
GO:0030182	neuron differentiation
GO:0030825	positive regulation of cGMP metabolic process
GO:0030855	epithelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060119	inner ear receptor cell development
GO:0060412	ventricular septum morphogenesis
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell