InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ANXA6

Summary

InnateDB Gene

IDBG-54213.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA6

Gene Name

annexin A6

Synonyms

ANX6; CBP68

Species

Homo sapiens

Ensembl Gene

ENSG00000197043

Encoded Proteins

IDBP-54215

annexin A6

IDBP-54219

annexin A6

IDBP-477162

annexin A6

IDBP-473416

annexin A6

IDBP-479853

annexin A6

IDBP-474621

annexin A6

IDBP-481109

annexin A6

IDBP-484246

annexin A6

IDBP-484792

annexin A6

IDBP-479711

annexin A6

IDBP-478152

annexin A6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:151100712-151157882

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000354546	ENSP00000346550
ENST00000377751	ENSP00000366980
ENST00000522664	ENSP00000431086
ENST00000523714	ENSP00000430517
ENST00000521512	ENSP00000430420
ENST00000517486	ENSP00000428916
ENST00000519644	ENSP00000430663
ENST00000520054
ENST00000517707
ENST00000517677	ENSP00000430826
ENST00000521749	ENSP00000430429
ENST00000517757	ENSP00000430572
ENST00000520378
ENST00000523164	ENSP00000431078
ENST00000519610

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008289	lipid binding
GO:0015276	ligand-gated ion channel activity
GO:0015485	cholesterol binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0034220	ion transmembrane transport
GO:0051260	protein homooligomerization

Cellular Component

GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0042470	melanosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018340

View Gene Order

ENSBTAG00000014809

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.412117

RefSeq

NM_001155 NM_001193544 XM_005268432

HUGO

OMIM

CCDS

CCDS47315 CCDS54941

HPRD

00231

IMGT

EMBL

GenPept

RNA Seq Atlas