Homo sapiens Gene: GFAP
Summary
InnateDB Gene IDBG-54485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFAP
Gene Name glial fibrillary acidic protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131095
Encoded Proteins
glial fibrillary acidic protein
glial fibrillary acidic protein
glial fibrillary acidic protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:44905008-44916937
Strand Reverse strand
Band q21.31
Transcripts
ENST00000253408 ENSP00000253408
ENST00000376990 ENSP00000366189
ENST00000435360 ENSP00000403962
ENST00000591880 ENSP00000467530
ENST00000588316 ENSP00000465629
ENST00000592065
ENST00000585728 ENSP00000465208
ENST00000585543
ENST00000589701
ENST00000591719
ENST00000586127 ENSP00000464795
ENST00000586793 ENSP00000468500
ENST00000587997 ENSP00000465624
ENST00000588640
ENST00000592706
ENST00000586125 ENSP00000467397
ENST00000588957 ENSP00000465565
ENST00000591327
ENST00000592320 ENSP00000465320
ENST00000588037 ENSP00000466163
ENST00000590922
ENST00000588735 ENSP00000466598
ENST00000593179 ENSP00000467106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0019900 kinase binding
Biological Process
GO:0009611 response to wounding
GO:0010625 positive regulation of Schwann cell proliferation
GO:0010977 negative regulation of neuron projection development
GO:0014002 astrocyte development
GO:0030198 extracellular matrix organization
GO:0031102 neuron projection regeneration
GO:0045103 intermediate filament-based process
GO:0045109 intermediate filament organization
GO:0051580 regulation of neurotransmitter uptake
GO:0060020 Bergmann glial cell differentiation
GO:0060252 positive regulation of glial cell proliferation
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0042995 cell projection
GO:0044297 cell body
GO:0097449 astrocyte projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by ERBB4 pathway
Signal Transduction pathway
Nuclear signaling by ERBB4 pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514227
RefSeq NM_001131019 NM_001242376 NM_002055
HUGO
OMIM
CCDS CCDS11491 CCDS45708 CCDS59296
HPRD 00675
IMGT
EMBL
GenPept
RNA Seq Atlas