Homo sapiens Gene: CTSO
Summary
InnateDB Gene IDBG-546402.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSO
Gene Name cathepsin O
Synonyms CTSO1;
Species Homo sapiens
Ensembl Gene ENSG00000256043
Encoded Proteins
cathepsin O
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:155924118-155953917
Strand Reverse strand
Band q32.1
Transcripts
ENST00000433477 ENSP00000414904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005764 lysosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P43234
TrEMBL
UniProt Splice Variant
Entrez Gene 1519
UniGene Hs.622293 Hs.75262
RefSeq NM_001334
HUGO HGNC:2542
OMIM 600550
CCDS CCDS3794
HPRD
IMGT
EMBL BC049206 X77383
GenPept AAH49206 CAA54562
RNA Seq Atlas 1519