Version 5.4
Homo sapiens Gene: CHMP4A
Summary
InnateDB Gene IDBG-547484.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP4A
Gene Name charged multivesicular body protein 4A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000254505
Encoded Proteins
IDBP-3677
Charged multivesicular body protein 4a
IDBP-604044
Charged multivesicular body protein 4a
IDBP-597732
Charged multivesicular body protein 4a
IDBP-601975
Charged multivesicular body protein 4a
IDBP-584351
Charged multivesicular body protein 4a
IDBP-812340
charged multivesicular body protein 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24209583-24213869
Strand Reverse strand
Band q12
Transcripts
ENST00000347519 ENSP00000324205
ENST00000530996 ENSP00000449757
ENST00000533523 ENSP00000436224
ENST00000542700
ENST00000533011 ENSP00000432575
ENST00000524955
ENST00000552620
ENST00000534106 ENSP00000448869
ENST00000527154
ENST00000531158
ENST00000609024 ENSP00000476412
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0051117 ATPase binding
Biological Process
GO:0006620 posttranslational protein targeting to membrane
GO:0006900 membrane budding
GO:0007034 vacuolar transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0051260 protein homooligomerization
GO:0061024 membrane organization
GO:0097320 membrane tubulation
GO:1901215 negative regulation of neuron death
GO:1902902 negative regulation of autophagic vacuole assembly
Cellular Component
GO:0000815 ESCRT III complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0030496 midbody
GO:0030659 cytoplasmic vesicle membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_014169
HUGO
OMIM
CCDS CCDS9619
HPRD 16597
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca