Homo sapiens Gene: FMNL1
Summary
InnateDB Gene IDBG-54756.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMNL1
Gene Name formin-like 1
Synonyms C17orf1; C17orf1B; FHOD4; FMNL; KW-13;
Species Homo sapiens
Ensembl Gene ENSG00000184922
Encoded Proteins
formin-like 1
formin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45221444-45247320
Strand Forward strand
Band q21.31
Transcripts
ENST00000331495 ENSP00000329219
ENST00000328118 ENSP00000327442
ENST00000586092 ENSP00000468301
ENST00000587489 ENSP00000465474
ENST00000586643 ENSP00000465137
ENST00000592006
ENST00000592415
ENST00000589911 ENSP00000466711
ENST00000592527
ENST00000587856
ENST00000585852
ENST00000591434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 71 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005488 binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0017048 Rho GTPase binding
GO:0032794 GTPase activating protein binding
GO:0048365 Rac GTPase binding
GO:0051015 actin filament binding
Biological Process
GO:0006929 substrate-dependent cell migration
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0009987 cellular process
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
GO:0030866 cortical actin cytoskeleton organization
GO:0051014 actin filament severing
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0032059 bleb
GO:0045335 phagocytic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.100217
RefSeq NM_005892 XM_006722067 XM_006722068
HUGO
OMIM
CCDS CCDS11497
HPRD 06876
IMGT
EMBL
GenPept
RNA Seq Atlas