Homo sapiens Gene: MCM2
Summary
InnateDB Gene IDBG-54871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM2
Gene Name minichromosome maintenance complex component 2
Synonyms BM28; CCNL1; cdc19; CDCL1; D3S3194; MITOTIN;
Species Homo sapiens
Ensembl Gene ENSG00000073111
Encoded Proteins
minichromosome maintenance complex component 2
minichromosome maintenance complex component 2
minichromosome maintenance complex component 2
minichromosome maintenance complex component 2
minichromosome maintenance complex component 2
minichromosome maintenance complex component 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:127598223-127622436
Strand Forward strand
Band q21.3
Transcripts
ENST00000265056 ENSP00000265056
ENST00000474964 ENSP00000420007
ENST00000480910 ENSP00000419802
ENST00000472731 ENSP00000418930
ENST00000477668 ENSP00000417800
ENST00000468659
ENST00000491422 ENSP00000420528
ENST00000473785
ENST00000468414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 123 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0042393 histone binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006334 nucleosome assembly
GO:0007049 cell cycle
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0032508 DNA duplex unwinding
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0042555 MCM complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Unwinding of DNA pathway
Cell Cycle pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
KEGG
DNA replication pathway
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.477481
RefSeq NM_004526
HUGO
OMIM
CCDS CCDS3043
HPRD 00303
IMGT
EMBL
GenPept
RNA Seq Atlas