Homo sapiens Gene: RUVBL1
Summary
InnateDB Gene IDBG-55108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUVBL1
Gene Name RuvB-like 1 (E. coli)
Synonyms ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A;
Species Homo sapiens
Ensembl Gene ENSG00000175792
Encoded Proteins
RuvB-like 1 (E. coli)
RuvB-like 1 (E. coli)
RuvB-like 1 (E. coli)
RuvB-like 1 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:128064778-128153914
Strand Reverse strand
Band q21.3
Transcripts
ENST00000322623 ENSP00000318297
ENST00000472125 ENSP00000417370
ENST00000464873 ENSP00000420738
ENST00000478892 ENSP00000417254
ENST00000480616
ENST00000478243
ENST00000585057 ENSP00000463669
ENST00000582176
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 208 [view]
Protein-Protein 205 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003678 DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007067 mitotic nuclear division
GO:0007283 spermatogenesis
GO:0032508 DNA duplex unwinding
GO:0034080 centromere-specific nucleosome assembly
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030529 ribonucleoprotein complex
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Telomere Maintenance pathway
Signal Transduction pathway
Cell Cycle pathway
Telomere Extension By Telomerase pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Extension of Telomeres pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional activation
Integrin-linked kinase signaling
C-MYC pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272822 Hs.619487
RefSeq NM_003707
HUGO
OMIM
CCDS CCDS3047
HPRD 09143
IMGT
EMBL
GenPept
RNA Seq Atlas