InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAPT

Summary

InnateDB Gene

IDBG-55163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPT

Gene Name

microtubule-associated protein tau

Synonyms

DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU

Species

Homo sapiens

Ensembl Gene

ENSG00000186868

Encoded Proteins

IDBP-55165

microtubule-associated protein tau

IDBP-55167

microtubule-associated protein tau

IDBP-55169

microtubule-associated protein tau

IDBP-55171

microtubule-associated protein tau

IDBP-55177

microtubule-associated protein tau

IDBP-361462

microtubule-associated protein tau

IDBP-361463

microtubule-associated protein tau

IDBP-361465

microtubule-associated protein tau

IDBP-380157

microtubule-associated protein tau

IDBP-584174

microtubule-associated protein tau

IDBP-764537

IDBP-761080

IDBP-763817

IDBP-764895

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer\'s disease, Pick\'s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:45894382-46028334

Strand

Forward strand

Band

q21.31

Transcripts

ENST00000344290	ENSP00000340820
ENST00000262410	ENSP00000262410
ENST00000351559	ENSP00000303214
ENST00000340799	ENSP00000340438
ENST00000334239	ENSP00000334886
ENST00000431008	ENSP00000389250
ENST00000415613	ENSP00000410838
ENST00000446361	ENSP00000408975
ENST00000420682	ENSP00000413056
ENST00000535772	ENSP00000443028
ENST00000570299
ENST00000576238
ENST00000571311	ENSP00000460048
ENST00000571987	ENSP00000458742
ENST00000577017
ENST00000574436	ENSP00000460965
ENST00000576518	ENSP00000458621
ENST00000572440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	128 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0034185	apolipoprotein binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007409	axonogenesis
GO:0007628	adult walking behavior
GO:0008088	axon cargo transport
GO:0010506	regulation of autophagy
GO:0031113	regulation of microtubule polymerization
GO:0031116	positive regulation of microtubule polymerization
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0048699	generation of neurons
GO:0060632	regulation of microtubule-based movement

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0015630	microtubule cytoskeleton
GO:0030424	axon
GO:0030426	growth cone
GO:0034399	nuclear periphery
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0045298	tubulin complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018411

View Gene Order

ENSBTAG00000017512

Not yet available

Pathways

NETPATH

NetPath_18

IL6 pathway

NetPath_22

Leptin pathway

REACTOME

REACT_13541

Caspase-mediated cleavage of cytoskeletal proteins pathway

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa05010

Alzheimer's disease pathway

INOH

PID NCI

lysophospholipid_pathway

LPA receptor mediated events

reelinpathway

Reelin signaling pathway

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

lkb1_pathway

LKB1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.101174

RefSeq

NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841 XM_005275647 XM_005275648 XM_006725266 XM_006725268 XM_006725269 XM_006725270 XM_006725271 XM_006725272 XM_006725273 XM_006725274 XM_006725275 XM_006725625

HUGO

OMIM

CCDS

CCDS11499 CCDS11500 CCDS11501 CCDS11502 CCDS45715 CCDS45716 CCDS56033

HPRD

01142

IMGT

EMBL

GenPept

RNA Seq Atlas