Homo sapiens Gene: MAPT
Summary
InnateDB Gene IDBG-55163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPT
Gene Name microtubule-associated protein tau
Synonyms DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU;
Species Homo sapiens
Ensembl Gene ENSG00000186868
Encoded Proteins
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer\'s disease, Pick\'s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45894382-46028334
Strand Forward strand
Band q21.31
Transcripts
ENST00000344290 ENSP00000340820
ENST00000262410 ENSP00000262410
ENST00000351559 ENSP00000303214
ENST00000340799 ENSP00000340438
ENST00000334239 ENSP00000334886
ENST00000431008 ENSP00000389250
ENST00000415613 ENSP00000410838
ENST00000446361 ENSP00000408975
ENST00000420682 ENSP00000413056
ENST00000535772 ENSP00000443028
ENST00000570299
ENST00000576238
ENST00000571311 ENSP00000460048
ENST00000571987 ENSP00000458742
ENST00000577017
ENST00000574436 ENSP00000460965
ENST00000576518 ENSP00000458621
ENST00000572440
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 129 [view]
Protein-Protein 128 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0034185 apolipoprotein binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007409 axonogenesis
GO:0007628 adult walking behavior
GO:0008088 axon cargo transport
GO:0010506 regulation of autophagy
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0032387 negative regulation of intracellular transport
GO:0045773 positive regulation of axon extension
GO:0047497 mitochondrion transport along microtubule
GO:0048675 axon extension
GO:0048699 generation of neurons
GO:0060632 regulation of microtubule-based movement
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0030426 growth cone
GO:0034399 nuclear periphery
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045298 tubulin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL6 pathway
Leptin pathway
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
KEGG
MAPK signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
Deregulation of cdk5 in alzheimers disease [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
PID NCI
LPA receptor mediated events
Reelin signaling pathway
Signaling mediated by p38-gamma and p38-delta
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.101174
RefSeq NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841 XM_005275647 XM_005275648 XM_006725266 XM_006725268 XM_006725269 XM_006725270 XM_006725271 XM_006725272 XM_006725273 XM_006725274 XM_006725275 XM_006725625
HUGO
OMIM
CCDS CCDS11499 CCDS11500 CCDS11501 CCDS11502 CCDS45715 CCDS45716 CCDS56033
HPRD 01142
IMGT
EMBL
GenPept
RNA Seq Atlas