Homo sapiens Gene: MAP4K2
Summary
InnateDB Gene IDBG-55181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4K2
Gene Name mitogen-activated protein kinase kinase kinase kinase 2
Synonyms BL44; GCK; RAB8IP;
Species Homo sapiens
Ensembl Gene ENSG00000168067
Encoded Proteins
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64788818-64803241
Strand Reverse strand
Band q13.1
Transcripts
ENST00000377350 ENSP00000366567
ENST00000294066 ENSP00000294066
ENST00000435926 ENSP00000400594
ENST00000424945 ENSP00000403410
ENST00000433890 ENSP00000413167
ENST00000439069 ENSP00000403563
ENST00000444560 ENSP00000404534
ENST00000470088
ENST00000489952
ENST00000467689
ENST00000493428
ENST00000482314
ENST00000468062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0006903 vesicle targeting
GO:0006955 immune response
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0000139 Golgi membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Tnf/stress related signaling [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.534341
RefSeq NM_004579
HUGO
OMIM
CCDS CCDS8082
HPRD 04408
IMGT
EMBL
GenPept
RNA Seq Atlas