Homo sapiens Gene: PRPF18
Summary
InnateDB Gene IDBG-55250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRPF18
Gene Name PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Synonyms hPrp18; PRP18
Species Homo sapiens
Ensembl Gene ENSG00000165630
Encoded Proteins
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:13586927-13630868
Strand Forward strand
Band p13
Transcripts
ENST00000378572 ENSP00000367835
ENST00000320054 ENSP00000367824
ENST00000417658 ENSP00000392142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019870 potassium channel inhibitor activity
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5T9P7
UniProt Splice Variant
Entrez Gene 8559
UniGene Hs.729158
RefSeq NM_003675
HUGO HGNC:17351
OMIM 604993
CCDS CCDS7100
HPRD 05407
IMGT
EMBL AL157392
GenPept
RNA Seq Atlas 8559