Version 5.4
Homo sapiens Gene: GOSR2
Summary
InnateDB Gene IDBG-55751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GOSR2
Gene Name golgi SNAP receptor complex member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108433
Encoded Proteins
IDBP-55753
golgi SNAP receptor complex member 2
IDBP-243594
golgi SNAP receptor complex member 2
IDBP-380279
golgi SNAP receptor complex member 2
IDBP-763106
IDBP-764289
IDBP-763680
IDBP-759764
IDBP-760515
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46923117-46967019
Strand Forward strand
Band q21.32
Transcripts
ENST00000225567 ENSP00000225567
ENST00000393456 ENSP00000377101
ENST00000415811 ENSP00000394559
ENST00000573224 ENSP00000461784
ENST00000571048
ENST00000575949 ENSP00000458911
ENST00000570879 ENSP00000458154
ENST00000572403 ENSP00000460760
ENST00000571658
ENST00000576910 ENSP00000461673
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
Biological Process
GO:0006810 transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0061025 membrane fusion
Cellular Component
GO:0000139 Golgi membrane
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463278 Hs.604565 Hs.614461
RefSeq NM_001012511 NM_004287 NM_054022 XM_005257844 XM_005257845
HUGO
OMIM
CCDS CCDS11507 CCDS42355 CCDS45719
HPRD 04937
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca