Version 5.4
Homo sapiens Gene: ALKBH2
Summary
InnateDB Gene IDBG-55757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALKBH2
Gene Name alkB, alkylation repair homolog 2 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000189046
Encoded Proteins
IDBP-55759
alkB, alkylation repair homolog 2 (E. coli)
IDBP-382709
alkB, alkylation repair homolog 2 (E. coli)
IDBP-382713
alkB, alkylation repair homolog 2 (E. coli)
IDBP-813736
alkB, alkylation repair homolog 2 (E. coli)
IDBP-595998
alkB, alkylation repair homolog 2 (E. coli)
IDBP-600368
alkB, alkylation repair homolog 2 (E. coli)
IDBP-813737
alkB, alkylation repair homolog 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109088188-109093631
Strand Reverse strand
Band q24.11
Transcripts
ENST00000343075 ENSP00000343021
ENST00000429722 ENSP00000398181
ENST00000440112 ENSP00000399820
ENST00000543444 ENSP00000474702
ENST00000536242 ENSP00000443042
ENST00000536358 ENSP00000444103
ENST00000536720
ENST00000619381 ENSP00000478765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734 DNA-N1-methyladenine dioxygenase activity
GO:0051747 cytosine C-5 DNA demethylase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0035511 oxidative DNA demethylation
GO:0055114 oxidation-reduction process
GO:0070989 oxidative demethylation
GO:0080111 DNA demethylation
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044339
View Gene Order
ENSBTAG00000019846
Not yet available
Pathways
NETPATH
REACTOME
REACT_526
ABH2 mediated Reversal of Alkylation Damage pathway
REACT_127
DNA Damage Reversal pathway
REACT_2020
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001001655 NM_001145374 NM_001145375 NM_001205179 NM_001205180
HUGO
OMIM
CCDS CCDS31897 CCDS55883
HPRD 14712
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca