InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFT122

Summary

InnateDB Gene

IDBG-55877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFT122

Gene Name

intraflagellar transport 122 homolog (Chlamydomonas)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163913

Encoded Proteins

IDBP-55879

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-55881

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-55883

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-55885

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-383833

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-383855

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-482849

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-484311

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-473563

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-478826

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-478413

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-481768

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-477837

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-477730

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-473429

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-482749

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-484991

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-483719

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-482196

intraflagellar transport 122 homolog (Chlamydomonas)

IDBP-478746

intraflagellar transport 122 homolog (Chlamydomonas)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:129440036-129520507

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000296266	ENSP00000296266
ENST00000348417	ENSP00000324005
ENST00000347300	ENSP00000323973
ENST00000349441	ENSP00000324165
ENST00000448668
ENST00000431818	ENSP00000410946
ENST00000440957	ENSP00000401569
ENST00000507564	ENSP00000425536
ENST00000512220	ENSP00000421953
ENST00000504021	ENSP00000422179
ENST00000506507
ENST00000509815
ENST00000504653
ENST00000510524	ENSP00000423902
ENST00000502304	ENSP00000427027
ENST00000508826	ENSP00000421140
ENST00000514275	ENSP00000423921
ENST00000502456	ENSP00000427061
ENST00000509195	ENSP00000425540
ENST00000512157	ENSP00000424206
ENST00000515783	ENSP00000423288
ENST00000511498	ENSP00000422237
ENST00000514081
ENST00000508654
ENST00000509522	ENSP00000424727
ENST00000513891
ENST00000512814
ENST00000511425
ENST00000507221	ENSP00000427515
ENST00000513932
ENST00000513190
ENST00000504444

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0007227	signal transduction downstream of smoothened
GO:0009953	dorsal/ventral pattern formation
GO:0010172	embryonic body morphogenesis
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0035050	embryonic heart tube development
GO:0035115	embryonic forelimb morphogenesis
GO:0035720	intraciliary anterograde transport
GO:0035721	intraciliary retrograde transport
GO:0042733	embryonic digit morphogenesis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060173	limb development
GO:0060271	cilium morphogenesis
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060971	embryonic heart tube left/right pattern formation
GO:0061512	protein localization to cilium
GO:0072594	establishment of protein localization to organelle

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0030991	intraciliary transport particle A
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0072372	primary cilium

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030323

View Gene Order

ENSBTAG00000019121

Not yet available

Pathways

NETPATH

REACTOME

REACT_228134

Signaling by Hedgehog pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D6R8Z2

UniProt Splice Variant

Entrez Gene

55764

UniGene

Hs.655284

RefSeq

NM_001280541 NM_001280545 NM_001280546 NM_018262 NM_052985 NM_052989 NM_052990 XM_005247603 XM_005247604 XM_005247608 XM_005247609 XM_005247610 XM_005247611 XM_006713689 XM_006713692 XM_006713693 XM_006713694 XM_006713695

HUGO

HGNC:13556

OMIM

606045

CCDS

CCDS3059 CCDS3060 CCDS3061 CCDS3062 CCDS63770 CCDS63772 CCDS63773

HPRD

06922

IMGT

EMBL

AC080007 AL449212

GenPept

RNA Seq Atlas

55764