Homo sapiens Gene: IFT122
Summary
InnateDB Gene IDBG-55877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFT122
Gene Name intraflagellar transport 122 homolog (Chlamydomonas)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163913
Encoded Proteins
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
intraflagellar transport 122 homolog (Chlamydomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:129440036-129520507
Strand Forward strand
Band q21.3
Transcripts
ENST00000296266 ENSP00000296266
ENST00000348417 ENSP00000324005
ENST00000347300 ENSP00000323973
ENST00000349441 ENSP00000324165
ENST00000448668
ENST00000431818 ENSP00000410946
ENST00000440957 ENSP00000401569
ENST00000507564 ENSP00000425536
ENST00000512220 ENSP00000421953
ENST00000504021 ENSP00000422179
ENST00000506507
ENST00000509815
ENST00000504653
ENST00000510524 ENSP00000423902
ENST00000502304 ENSP00000427027
ENST00000508826 ENSP00000421140
ENST00000514275 ENSP00000423921
ENST00000502456 ENSP00000427061
ENST00000509195 ENSP00000425540
ENST00000512157 ENSP00000424206
ENST00000515783 ENSP00000423288
ENST00000511498 ENSP00000422237
ENST00000514081
ENST00000508654
ENST00000509522 ENSP00000424727
ENST00000513891
ENST00000512814
ENST00000511425
ENST00000507221 ENSP00000427515
ENST00000513932
ENST00000513190
ENST00000504444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001843 neural tube closure
GO:0007227 signal transduction downstream of smoothened
GO:0009953 dorsal/ventral pattern formation
GO:0010172 embryonic body morphogenesis
GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0035050 embryonic heart tube development
GO:0035115 embryonic forelimb morphogenesis
GO:0035720 intraciliary anterograde transport
GO:0035721 intraciliary retrograde transport
GO:0042733 embryonic digit morphogenesis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048593 camera-type eye morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060173 limb development
GO:0060271 cilium morphogenesis
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061512 protein localization to cilium
GO:0072594 establishment of protein localization to organelle
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030991 intraciliary transport particle A
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by Hedgehog pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H7C3C0
UniProt Splice Variant
Entrez Gene 55764
UniGene Hs.655284
RefSeq NM_001280545 XM_006713693 NM_052985 NM_018262 NM_001280541 NM_052990 NM_052989 NM_001280546 XM_005247610 XM_005247609 XM_005247608 XM_006713692 XM_006713694 XM_005247611 XM_006713695 XM_005247604 XM_006713689 XM_005247603
HUGO HGNC:13556
OMIM 606045
CCDS CCDS63772 CCDS3060 CCDS3059 CCDS63770 CCDS3062 CCDS3061 CCDS63773
HPRD 06922
IMGT
EMBL AC080007 AL449212 CH471052
GenPept EAW79246
RNA Seq Atlas 55764