Homo sapiens Gene: ITGB2 | |||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-5590.6 | ||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
Gene Symbol | ITGB2 | ||||||||||||||||||||||||||||||||||||
Gene Name | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | ||||||||||||||||||||||||||||||||||||
Synonyms | CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7 | ||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000160255 | ||||||||||||||||||||||||||||||||||||
Encoded Proteins |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
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Protein Structure | |||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||
Summary |
ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)
ITGB2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.
ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.
[Mus musculus] Itgb2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs. (Demonstrated in human)
[Mus musculus] Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||
Summary |
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 21:44885953-44931989 | ||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
Band | q22.3 | ||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||
REACTOME |
Toll Like Receptor 4 (TLR4) Cascade pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Cell surface interactions at the vascular wall pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Natural killer cell mediated cytotoxicity pathway
Viral myocarditis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Amoebiasis pathway
Malaria pathway
Phagosome pathway
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INOH |
Integrin signaling pathway pathway
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PID NCI |
Integrin family cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
HIF-1-alpha transcription factor network
amb2 Integrin signaling
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Cross-References | |||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||
UniGene | Hs.375957 | ||||||||||||||||||||||||||||||||||||
RefSeq | NM_000211 NM_001127491 XM_006724001 | ||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||
CCDS | CCDS13716 | ||||||||||||||||||||||||||||||||||||
HPRD | 02506 | ||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||