InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KPNB1

Summary

InnateDB Gene

IDBG-56053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNB1

Gene Name

karyopherin (importin) beta 1

Synonyms

IMB1; Impnb; IPO1; IPOB; NTF97

Species

Homo sapiens

Ensembl Gene

ENSG00000108424

Encoded Proteins

IDBP-56055

karyopherin (importin) beta 1

IDBP-591309

karyopherin (importin) beta 1

IDBP-593699

karyopherin (importin) beta 1

IDBP-761460

IDBP-758340

IDBP-758498

IDBP-759663

IDBP-760226

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:47649476-47685505

Strand

Forward strand

Band

q21.32

Transcripts

ENST00000290158	ENSP00000290158
ENST00000535458	ENSP00000438253
ENST00000540627	ENSP00000438964
ENST00000583013	ENSP00000463190
ENST00000582126	ENSP00000462243
ENST00000580019
ENST00000578718
ENST00000577918
ENST00000580158
ENST00000582097	ENSP00000463066
ENST00000579901
ENST00000580573
ENST00000577875	ENSP00000464200
ENST00000583648	ENSP00000464042

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	179 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006309	apoptotic DNA fragmentation
GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0006610	ribosomal protein import into nucleus
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0015031	protein transport
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0075733	intracellular transport of virus

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071782	endoplasmic reticulum tubular network