Version 5.4
Homo sapiens Gene: DSTN
Summary
InnateDB Gene IDBG-56056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSTN
Gene Name destrin (actin depolymerizing factor)
Synonyms ACTDP; ADF; bA462D18.2; HEL32
Species Homo sapiens
Ensembl Gene ENSG00000125868
Encoded Proteins
IDBP-56058
destrin (actin depolymerizing factor)
IDBP-595081
destrin (actin depolymerizing factor)
IDBP-811106
destrin (actin depolymerizing factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:17569863-17609919
Strand Forward strand
Band p12.1
Transcripts
ENST00000246069 ENSP00000246069
ENST00000449141 ENSP00000434355
ENST00000474024 ENSP00000476975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006928 cellular component movement
GO:0008154 actin polymerization or depolymerization
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0051014 actin filament severing
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015932
View Gene Order
ENSBTAG00000015434
Not yet available
Cross-References
SwissProt
TrEMBL F6RFD5
UniProt Splice Variant
Entrez Gene 11034
UniGene Hs.304192 Hs.705996
RefSeq NM_001011546 NM_006870
HUGO HGNC:15750
OMIM 609114
CCDS CCDS13127 CCDS46580
HPRD 16446
IMGT
EMBL AL132765
GenPept
RNA Seq Atlas 11034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca