Homo sapiens Gene: GMDS
Summary
InnateDB Gene IDBG-56146.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMDS
Gene Name GDP-mannose 4,6-dehydratase
Synonyms GMD; SDR3E1;
Species Homo sapiens
Ensembl Gene ENSG00000112699
Encoded Proteins
GDP-mannose 4,6-dehydratase
GDP-mannose 4,6-dehydratase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:1623806-2245692
Strand Reverse strand
Band p25.3
Transcripts
ENST00000380815 ENSP00000370194
ENST00000380805
ENST00000486793
ENST00000467288
ENST00000476972
ENST00000530927 ENSP00000436726
ENST00000533279
ENST00000531690
ENST00000530459
ENST00000530075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008446 GDP-mannose 4,6-dehydratase activity
GO:0050662 coenzyme binding
GO:0070401 NADP+ binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0019673 GDP-mannose metabolic process
GO:0042351 'de novo' GDP-L-fucose biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Fructose and mannose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
INOH
Fructose Mannose metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.144496
RefSeq NM_001253846 NM_001500
HUGO
OMIM
CCDS CCDS4474 CCDS58994
HPRD 11925
IMGT
EMBL
GenPept
RNA Seq Atlas