Homo sapiens Gene: PTTG1
Summary
InnateDB Gene IDBG-56181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTTG1
Gene Name pituitary tumor-transforming 1
Synonyms EAP1; HPTTG; PTTG; TUTR1;
Species Homo sapiens
Ensembl Gene ENSG00000164611
Encoded Proteins
pituitary tumor-transforming 1
pituitary tumor-transforming 1
pituitary tumor-transforming 1
pituitary tumor-transforming 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008]
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:160421822-160428744
Strand Forward strand
Band q33.3
Transcripts
ENST00000352433 ENSP00000344936
ENST00000393964 ENSP00000377536
ENST00000524244
ENST00000517480 ENSP00000431068
ENST00000523659
ENST00000520452 ENSP00000430642
ENST00000519287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 51 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007283 spermatogenesis
GO:0010951 negative regulation of endopeptidase activity
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Separation of Sister Chromatids pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95997
TrEMBL C4TNW4 Q2VPE7 Q6IAL9
UniProt Splice Variant
Entrez Gene 9232
UniGene
RefSeq NM_001282382 NM_004219 NM_001282383
HUGO HGNC:9690
OMIM 604147
CCDS CCDS4353
HPRD 04998
IMGT
EMBL AB505430 AF075242 AF095287 AF167560 AF167561 AF167562 AF167563 AF167564 AJ223953 AK312209 BC101834 BC108894 BC108895 BC112071 BC113842 BC113896 BC128193 BC128194 CH471062 CR457135 CR541685
GenPept AAC64409 AAD19335 AAF06995 AAI01835 AAI08895 AAI08896 AAI12072 AAI13843 AAI13897 AAI28194 AAI28195 BAG35142 BAH69082 CAA11683 CAG33416 CAG46486 EAW61551 EAW61552 EAW61553
RNA Seq Atlas 9232