Version 5.4
Homo sapiens Gene: SNX5
Summary
InnateDB Gene IDBG-56465.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX5
Gene Name sorting nexin 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089006
Encoded Proteins
IDBP-56467
sorting nexin 5
IDBP-56469
sorting nexin 5
IDBP-367647
sorting nexin 5
IDBP-367648
sorting nexin 5
IDBP-806586
sorting nexin 5
IDBP-806594
sorting nexin 5
IDBP-806596
sorting nexin 5
IDBP-806591
sorting nexin 5
IDBP-806592
sorting nexin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein binds to fanconi anemia complementation group A protein, but its function is unknown. This gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:17941597-17968980
Strand Reverse strand
Band p11.23
Transcripts
ENST00000377768 ENSP00000366998
ENST00000377759 ENSP00000366988
ENST00000431277 ENSP00000404448
ENST00000419004 ENSP00000406731
ENST00000490175
ENST00000483485
ENST00000484809
ENST00000491090
ENST00000476648
ENST00000463050 ENSP00000479021
ENST00000494401
ENST00000474883
ENST00000475716
ENST00000469704
ENST00000481323 ENSP00000475606
ENST00000486039 ENSP00000475983
ENST00000606570
ENST00000606557 ENSP00000475510
ENST00000606602 ENSP00000476097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 37 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006907 pinocytosis
Cellular Component
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0030659 cytoplasmic vesicle membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031313 extrinsic component of endosome membrane
GO:0031901 early endosome membrane
GO:0070685 macropinocytic cup
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027423
View Gene Order
ENSBTAG00000003422
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.316890
RefSeq NM_001282454 NM_014426 NM_152227
HUGO
OMIM
CCDS CCDS13130
HPRD 10439
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca