Version 5.4
Homo sapiens Gene: TM7SF2
Summary
InnateDB Gene IDBG-56494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TM7SF2
Gene Name transmembrane 7 superfamily member 2
Synonyms ANG1; DHCR14A; NET47
Species Homo sapiens
Ensembl Gene ENSG00000149809
Encoded Proteins
IDBP-56496
transmembrane 7 superfamily member 2
IDBP-56498
transmembrane 7 superfamily member 2
IDBP-594532
transmembrane 7 superfamily member 2
IDBP-584580
transmembrane 7 superfamily member 2
IDBP-601087
transmembrane 7 superfamily member 2
IDBP-588451
transmembrane 7 superfamily member 2
IDBP-600950
transmembrane 7 superfamily member 2
IDBP-597470
transmembrane 7 superfamily member 2
IDBP-595348
transmembrane 7 superfamily member 2
IDBP-594375
transmembrane 7 superfamily member 2
IDBP-603030
transmembrane 7 superfamily member 2
IDBP-595063
transmembrane 7 superfamily member 2
IDBP-600574
transmembrane 7 superfamily member 2
IDBP-590009
transmembrane 7 superfamily member 2
IDBP-596628
transmembrane 7 superfamily member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65111845-65116384
Strand Forward strand
Band q13.1
Transcripts
ENST00000279263 ENSP00000279263
ENST00000345348 ENSP00000329520
ENST00000526809 ENSP00000432171
ENST00000524986 ENSP00000435972
ENST00000528026
ENST00000533766
ENST00000534371 ENSP00000432187
ENST00000533646
ENST00000529601 ENSP00000435458
ENST00000525385 ENSP00000433325
ENST00000531321 ENSP00000431300
ENST00000529292 ENSP00000436370
ENST00000529414 ENSP00000433275
ENST00000526085 ENSP00000434447
ENST00000530650
ENST00000530750 ENSP00000432413
ENST00000524690 ENSP00000434598
ENST00000530892
ENST00000531029
ENST00000529233
ENST00000527851
ENST00000534667
ENST00000532328
ENST00000527968 ENSP00000431685
ENST00000528802 ENSP00000436233
ENST00000526048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0050613 delta14-sterol reductase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024799
View Gene Order
ENSBTAG00000005069
Not yet available
Pathways
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.31130
RefSeq NM_001277233 NM_003273
HUGO
OMIM
CCDS CCDS41669 CCDS60846
HPRD 04564
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca