Homo sapiens Gene: MAT2B
Summary
InnateDB Gene IDBG-56645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAT2B
Gene Name methionine adenosyltransferase II, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000038274
Encoded Proteins
methionine adenosyltransferase II, beta
methionine adenosyltransferase II, beta
methionine adenosyltransferase II, beta
methionine adenosyltransferase II, beta
methionine adenosyltransferase II, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:163503114-163519336
Strand Forward strand
Band q34
Transcripts
ENST00000280969 ENSP00000280969
ENST00000321757 ENSP00000325425
ENST00000421814 ENSP00000397371
ENST00000519719
ENST00000518095 ENSP00000428046
ENST00000523606
ENST00000520449 ENSP00000431071
ENST00000521838
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 31 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831 dTDP-4-dehydrorhamnose reductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019899 enzyme binding
GO:0048270 methionine adenosyltransferase regulator activity
GO:0050662 coenzyme binding
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006694 steroid biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0006805 xenobiotic metabolic process
GO:0009058 biosynthetic process
GO:0032259 methylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0050790 regulation of catalytic activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0048269 methionine adenosyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Methylation pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Cysteine and methionine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.54642 Hs.713572
RefSeq NM_013283 NM_182796
HUGO
OMIM
CCDS CCDS4364 CCDS4365
HPRD 05701
IMGT
EMBL
GenPept
RNA Seq Atlas