Version 5.4
Homo sapiens Gene: ACTG2
Summary
InnateDB Gene IDBG-56729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTG2
Gene Name actin, gamma 2, smooth muscle, enteric
Synonyms ACT; ACTA3; ACTE; ACTL3; ACTSG; VSCM
Species Homo sapiens
Ensembl Gene ENSG00000163017
Encoded Proteins
IDBP-56731
actin, gamma 2, smooth muscle, enteric
IDBP-295545
actin, gamma 2, smooth muscle, enteric
IDBP-295541
actin, gamma 2, smooth muscle, enteric
IDBP-295543
actin, gamma 2, smooth muscle, enteric
IDBP-380212
actin, gamma 2, smooth muscle, enteric
IDBP-380216
actin, gamma 2, smooth muscle, enteric
IDBP-380219
actin, gamma 2, smooth muscle, enteric
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73892314-73919865
Strand Forward strand
Band p13.1
Transcripts
ENST00000345517 ENSP00000295137
ENST00000409731 ENSP00000386929
ENST00000409624 ENSP00000386857
ENST00000409918 ENSP00000387182
ENST00000438902 ENSP00000410706
ENST00000429756 ENSP00000392894
ENST00000442912 ENSP00000410020
ENST00000473016
ENST00000468543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
Biological Process
GO:0006936 muscle contraction
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0071944 cell periphery
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000059430
View Gene Order
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001199893 NM_001615
HUGO
OMIM
CCDS CCDS1930 CCDS56124
HPRD 00016
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca