Homo sapiens Gene: DOCK2
Summary
InnateDB Gene IDBG-57108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK2
Gene Name dedicator of cytokinesis 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134516
Encoded Proteins
dedicator of cytokinesis 2
dedicator of cytokinesis 2
dedicator of cytokinesis 2
dedicator of cytokinesis 2
dedicator of cytokinesis 2
dedicator of cytokinesis 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:169637247-170083382
Strand Forward strand
Band q35.1
Transcripts
ENST00000256935 ENSP00000256935
ENST00000433448 ENSP00000393451
ENST00000522138
ENST00000524185 ENSP00000428850
ENST00000523684
ENST00000519734
ENST00000519223
ENST00000520908 ENSP00000429283
ENST00000520836
ENST00000520181
ENST00000519628 ENSP00000428841
ENST00000523351
ENST00000522994
ENST00000518056
ENST00000520450
ENST00000519868
ENST00000540750 ENSP00000438827
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
GO:0030675 Rac GTPase activator activity
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0042608 T cell receptor binding
Biological Process
GO:0001766 membrane raft polarization
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0006935 chemotaxis
GO:0007010 cytoskeleton organization
GO:0007264 small GTPase mediated signal transduction
GO:0016032 viral process
GO:0030036 actin cytoskeleton organization
GO:0032855 positive regulation of Rac GTPase activity
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0043547 positive regulation of GTPase activity
GO:0044351 macropinocytosis
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0046631 alpha-beta T cell activation
GO:0046633 alpha-beta T cell proliferation
GO:0050690 regulation of defense response to virus by virus
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TCR pathway
TSLP pathway
REACTOME
Nef and signal transduction pathway
Factors involved in megakaryocyte development and platelet production pathway
HIV Infection pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
IL8- and CXCR2-mediated signaling events
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL B3KXW9 E7ERW7 Q5XG91
UniProt Splice Variant
Entrez Gene 1794
UniGene Hs.586174 Hs.684170
RefSeq NM_004946 XM_005265830
HUGO HGNC:2988
OMIM 603122
CCDS CCDS4371
HPRD 09121
IMGT
EMBL AC008449 AC008648 AC008680 AC010303 AC026695 AK128107 BC084556
GenPept AAH84556 BAG54631
RNA Seq Atlas 1794