InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DOCK2

Summary

InnateDB Gene

IDBG-57108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK2

Gene Name

dedicator of cytokinesis 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134516

Encoded Proteins

IDBP-57110

dedicator of cytokinesis 2

IDBP-364426

dedicator of cytokinesis 2

IDBP-481004

dedicator of cytokinesis 2

IDBP-482804

dedicator of cytokinesis 2

IDBP-474492

dedicator of cytokinesis 2

IDBP-600869

dedicator of cytokinesis 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:169637247-170083382

Strand

Forward strand

Band

q35.1

Transcripts

ENST00000256935	ENSP00000256935
ENST00000433448	ENSP00000393451
ENST00000522138
ENST00000524185	ENSP00000428850
ENST00000523684
ENST00000519734
ENST00000519223
ENST00000520908	ENSP00000429283
ENST00000520836
ENST00000520181
ENST00000519628	ENSP00000428841
ENST00000523351
ENST00000522994
ENST00000518056
ENST00000520450
ENST00000519868
ENST00000540750	ENSP00000438827

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0030675	Rac GTPase activator activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042608	T cell receptor binding

Biological Process

GO:0001766	membrane raft polarization
GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002277	myeloid dendritic cell activation involved in immune response
GO:0006935	chemotaxis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0016032	viral process
GO:0030036	actin cytoskeleton organization
GO:0032855	positive regulation of Rac GTPase activity
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0043547	positive regulation of GTPase activity
GO:0044351	macropinocytosis
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0046631	alpha-beta T cell activation
GO:0046633	alpha-beta T cell proliferation
GO:0050690	regulation of defense response to virus by virus
GO:0050766	positive regulation of phagocytosis