InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POLR3F

Summary

InnateDB Gene

IDBG-57193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR3F

Gene Name

polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

Synonyms

RPC39; RPC6

Species

Homo sapiens

Ensembl Gene

ENSG00000132664

Encoded Proteins

IDBP-57195

polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:18467127-18484643

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000377603	ENSP00000366828
ENST00000461589
ENST00000462997
ENST00000497333
ENST00000475192
ENST00000489753

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006359	regulation of transcription from RNA polymerase III promoter
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0051607	defense response to virus