Homo sapiens Gene: LCP2
Summary
InnateDB Gene IDBG-57216.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LCP2
Gene Name lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Synonyms SLP-76; SLP76
Species Homo sapiens
Ensembl Gene ENSG00000043462
Encoded Proteins
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Lcp2 is a critical determinant of natural killer (NK)-cell development and NK cell mediated elimination of missing-self target cells.
Entrez Gene
Summary SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72%% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:170246237-170298227
Strand Reverse strand
Band q35.1
Transcripts
ENST00000046794 ENSP00000046794
ENST00000520322
ENST00000521416 ENSP00000428871
ENST00000523369
ENST00000520344 ENSP00000430391
ENST00000519594
ENST00000522760
ENST00000522823
ENST00000519149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045576 mast cell activation
GO:0050663 cytokine secretion
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005911 cell-cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
TCR pathway
BCR pathway
REACTOME
DAP12 signaling pathway
DAP12 interactions pathway
Generation of second messenger molecules pathway
GPVI-mediated activation cascade pathway
TCR signaling pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Adaptive Immune System pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
KEGG
Fc epsilon RI signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
INOH
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
JNK signaling in the CD4+ TCR pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.304475 Hs.660173 Hs.666017
RefSeq NM_005565
HUGO
OMIM
CCDS CCDS47339
HPRD 03362
IMGT
EMBL
GenPept
RNA Seq Atlas