Homo sapiens Gene: MARK4
Summary
InnateDB Gene IDBG-57219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARK4
Gene Name MAP/microtubule affinity-regulating kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000007047
Encoded Proteins
MAP/microtubule affinity-regulating kinase 4
MAP/microtubule affinity-regulating kinase 4
MAP/microtubule affinity-regulating kinase 4
MAP/microtubule affinity-regulating kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45079288-45305283
Strand Forward strand
Band q13.32
Transcripts
ENST00000300843 ENSP00000300843
ENST00000262891 ENSP00000262891
ENST00000592762 ENSP00000466702
ENST00000587566 ENSP00000465414
ENST00000590897
ENST00000590909 ENSP00000465613
ENST00000588621
ENST00000592207 ENSP00000466843
ENST00000588533
ENST00000622871 ENSP00000484974
ENST00000620044 ENSP00000480702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043015 gamma-tubulin binding
GO:0043130 ubiquitin binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0006468 protein phosphorylation
GO:0007399 nervous system development
GO:0043068 positive regulation of programmed cell death
Cellular Component
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0015630 microtubule cytoskeleton
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.34314
RefSeq NM_001199867 NM_031417 XM_006723307
HUGO
OMIM
CCDS CCDS12658 CCDS56097
HPRD 09402
IMGT
EMBL
GenPept
RNA Seq Atlas