InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MARK4

Summary

InnateDB Gene

IDBG-57219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARK4

Gene Name

MAP/microtubule affinity-regulating kinase 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000007047

Encoded Proteins

IDBP-57221

MAP/microtubule affinity-regulating kinase 4

IDBP-57223

MAP/microtubule affinity-regulating kinase 4

IDBP-765728

IDBP-765351

IDBP-759939

IDBP-761531

IDBP-807013

MAP/microtubule affinity-regulating kinase 4

IDBP-807014

MAP/microtubule affinity-regulating kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45079288-45305283

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000300843	ENSP00000300843
ENST00000262891	ENSP00000262891
ENST00000592762	ENSP00000466702
ENST00000587566	ENSP00000465414
ENST00000590897
ENST00000590909	ENSP00000465613
ENST00000588621
ENST00000592207	ENSP00000466843
ENST00000588533
ENST00000622871	ENSP00000484974
ENST00000620044	ENSP00000480702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043015	gamma-tubulin binding
GO:0043130	ubiquitin binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0043068	positive regulation of programmed cell death

Cellular Component

GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0015630	microtubule cytoskeleton
GO:0043005	neuron projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030397

View Gene Order

ENSBTAG00000002682

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

lkb1_pathway

LKB1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.34314

RefSeq

NM_001199867 NM_031417 XM_006723307

HUGO

OMIM

CCDS

CCDS12658 CCDS56097

HPRD

09402

IMGT

EMBL

GenPept

RNA Seq Atlas