Homo sapiens Gene: NPM1
Summary
InnateDB Gene IDBG-57453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPM1
Gene Name nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Synonyms B23; NPM;
Species Homo sapiens
Ensembl Gene ENSG00000181163
Encoded Proteins
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:171387116-171411137
Strand Forward strand
Band q35.1
Transcripts
ENST00000296930 ENSP00000296930
ENST00000351986 ENSP00000341168
ENST00000393820 ENSP00000377408
ENST00000517671 ENSP00000428755
ENST00000521672 ENSP00000429485
ENST00000523339
ENST00000523622 ENSP00000428647
ENST00000518587
ENST00000521260
ENST00000521710
ENST00000519955
ENST00000524204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 440 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 441 [view]
Protein-Protein 438 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030957 Tat protein binding
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0051059 NF-kappaB binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006281 DNA repair
GO:0006334 nucleosome assembly
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0006950 response to stress
GO:0007098 centrosome cycle
GO:0007165 signal transduction
GO:0007569 cell aging
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0010826 negative regulation of centrosome duplication
GO:0016032 viral process
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0034080 centromere-specific nucleosome assembly
GO:0042255 ribosome assembly
GO:0043066 negative regulation of apoptotic process
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045727 positive regulation of translation
GO:0046599 regulation of centriole replication
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0060699 regulation of endoribonuclease activity
GO:0060735 regulation of eIF2 alpha phosphorylation by dsRNA
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0031616 spindle pole centrosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Cell Cycle pathway
HIV Infection pathway
Nuclear import of Rev protein pathway
Host Interactions of HIV factors pathway
Interactions of Rev with host cellular proteins pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional activation
HIF-1-alpha transcription factor network
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.573436 Hs.600877 Hs.634598 Hs.647621 Hs.667403 Hs.735618
RefSeq NM_001037738 NM_002520 NM_199185 XM_006714869
HUGO
OMIM
CCDS CCDS43399 CCDS4376 CCDS4377
HPRD 01246
IMGT
EMBL
GenPept
RNA Seq Atlas