Homo sapiens Gene: GNGT2
Summary
InnateDB Gene IDBG-57490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNGT2
Gene Name guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
Synonyms G-GAMMA-8; G-GAMMA-C; GNG8; GNG9; GNGT8;
Species Homo sapiens
Ensembl Gene ENSG00000167083
Encoded Proteins
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49202791-49210574
Strand Reverse strand
Band q21.32
Transcripts
ENST00000300406 ENSP00000300406
ENST00000503070 ENSP00000420946
ENST00000511277 ENSP00000426022
ENST00000515635 ENSP00000423924
ENST00000507680 ENSP00000421710
ENST00000511673 ENSP00000422879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
Biological Process
GO:0006184 GTP catabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007602 phototransduction
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
ADP signalling through P2Y purinoceptor 12 pathway
Presynaptic function of Kainate receptors pathway
Transmembrane transport of small molecules pathway
G alpha (12/13) signalling events pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
beta-catenin independent WNT signaling pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Prostacyclin signalling through prostacyclin receptor pathway
GABA receptor activation pathway
G protein gated Potassium channels pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Glucagon-type ligand receptors pathway
G-protein activation pathway
Inwardly rectifying K+ channels pathway
Activation of Kainate Receptors upon glutamate binding pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Platelet homeostasis pathway
G alpha (z) signalling events pathway
Potassium Channels pathway
GABA B receptor activation pathway
Thromboxane signalling through TP receptor pathway
Transmission across Chemical Synapses pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
ADP signalling through P2Y purinoceptor 1 pathway
G beta:gamma signalling through PLC beta pathway
GPCR ligand binding pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Signal amplification pathway
Activation of G protein gated Potassium channels pathway
Class B/2 (Secretin family receptors) pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
Visual signal transduction [Biocarta view]
PID NCI
Visual signal transduction: Cones
Cross-References
SwissProt O14610
TrEMBL
UniProt Splice Variant
Entrez Gene 2793
UniGene
RefSeq NM_001198755 NM_031498 NM_001198756 NM_001198754 XM_006721819
HUGO HGNC:4412
OMIM 139391
CCDS CCDS11545
HPRD 06792
IMGT
EMBL AF001159 AF001160 AF365870 AF493876 AK312839 BC008663 CH471109
GenPept AAB70039 AAH08663 AAK53384 AAM12590 BAG35693 EAW94688 EAW94689
RNA Seq Atlas 2793