Homo sapiens Gene: FGF18
Summary
InnateDB Gene IDBG-57567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF18
Gene Name fibroblast growth factor 18
Synonyms FGF-18; ZFGF5;
Species Homo sapiens
Ensembl Gene ENSG00000156427
Encoded Proteins
fibroblast growth factor 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:171419656-171457623
Strand Forward strand
Band q35.1
Transcripts
ENST00000274625 ENSP00000274625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001957 intramembranous ossification
GO:0001958 endochondral ossification
GO:0002063 chondrocyte development
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0030324 lung development
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032332 positive regulation of chondrocyte differentiation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR3 mutants pathway
Signaling by FGFR mutants pathway
Activated point mutants of FGFR2 pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
FRS2-mediated cascade pathway
Phospholipase C-mediated cascade pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
FGFR2c ligand binding and activation pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
FGFR3b ligand binding and activation pathway
FGFR3 ligand binding and activation pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
FGFR3c ligand binding and activation pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Negative regulation of FGFR signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Signaling by activated point mutants of FGFR3 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
FGFR4 ligand binding and activation pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Melanoma pathway
INOH
GPCR signaling pathway
FGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O76093
TrEMBL
UniProt Splice Variant
Entrez Gene 8817
UniGene Hs.87191
RefSeq NM_003862
HUGO HGNC:3674
OMIM 603726
CCDS CCDS4378
HPRD 04766
IMGT
EMBL AB007422 AF075292 AF211188 AY358811 BC006245 BT019570 BT019571 CH471062
GenPept AAC62240 AAF22977 AAH06245 AAQ89954 AAV38377 AAV38378 BAA31986 EAW61441 EAW61442
RNA Seq Atlas 8817