Homo sapiens Gene: KAT5
Summary
InnateDB Gene IDBG-57604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAT5
Gene Name K(lysine) acetyltransferase 5
Synonyms cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5;
Species Homo sapiens
Ensembl Gene ENSG00000172977
Encoded Proteins
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
K(lysine) acetyltransferase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65711996-65719604
Strand Forward strand
Band q13.1
Transcripts
ENST00000341318 ENSP00000340330
ENST00000377046 ENSP00000366245
ENST00000352980 ENSP00000344955
ENST00000532042
ENST00000530446 ENSP00000434765
ENST00000534104 ENSP00000435939
ENST00000530605 ENSP00000436247
ENST00000534293
ENST00000527544
ENST00000528198 ENSP00000436000
ENST00000531880 ENSP00000436012
ENST00000534650 ENSP00000431819
ENST00000525204
ENST00000534681 ENSP00000434993
ENST00000533441
ENST00000525600
ENST00000533596 ENSP00000435766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 274 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 274 [view]
Protein-Protein 259 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032403 protein complex binding
GO:0046872 metal ion binding
GO:0050681 androgen receptor binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006302 double-strand break repair
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010212 response to ionizing radiation
GO:0016032 viral process
GO:0016573 histone acetylation
GO:0030521 androgen receptor signaling pathway
GO:0032703 negative regulation of interleukin-2 production
GO:0040008 regulation of growth
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0032777 Piccolo NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
IL9 pathway
REACTOME
HATs acetylate histones pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
Multi-step regulation of transcription by pitx2 [Biocarta view]
PID NCI
ATF-2 transcription factor network
Validated targets of C-MYC transcriptional activation
p53 pathway
p73 transcription factor network
C-MYC pathway
ATM pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.397010
RefSeq NM_001206833 NM_006388 NM_182709 NM_182710
HUGO
OMIM
CCDS CCDS31610 CCDS55771 CCDS8109 CCDS8110
HPRD 03245
IMGT
EMBL
GenPept
RNA Seq Atlas