InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KAT5

Summary

InnateDB Gene

IDBG-57604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT5

Gene Name

K(lysine) acetyltransferase 5

Synonyms

cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5

Species

Homo sapiens

Ensembl Gene

ENSG00000172977

Encoded Proteins

IDBP-57606

K(lysine) acetyltransferase 5

IDBP-57608

K(lysine) acetyltransferase 5

IDBP-57610

K(lysine) acetyltransferase 5

IDBP-590982

K(lysine) acetyltransferase 5

IDBP-587558

K(lysine) acetyltransferase 5

IDBP-591101

K(lysine) acetyltransferase 5

IDBP-598805

K(lysine) acetyltransferase 5

IDBP-601383

K(lysine) acetyltransferase 5

IDBP-597057

K(lysine) acetyltransferase 5

IDBP-589377

K(lysine) acetyltransferase 5

IDBP-601390

K(lysine) acetyltransferase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65711996-65719604

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000341318	ENSP00000340330
ENST00000377046	ENSP00000366245
ENST00000352980	ENSP00000344955
ENST00000532042
ENST00000530446	ENSP00000434765
ENST00000534104	ENSP00000435939
ENST00000530605	ENSP00000436247
ENST00000534293
ENST00000527544
ENST00000528198	ENSP00000436000
ENST00000531880	ENSP00000436012
ENST00000534650	ENSP00000431819
ENST00000525204
ENST00000534681	ENSP00000434993
ENST00000533441
ENST00000525600
ENST00000533596	ENSP00000435766

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 274 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	274 [view]
Protein-Protein	259 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006302	double-strand break repair
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010212	response to ionizing radiation
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0030521	androgen receptor signaling pathway
GO:0032703	negative regulation of interleukin-2 production
GO:0040008	regulation of growth
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000785	chromatin
GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0032777	Piccolo NuA4 histone acetyltransferase complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm