InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXW11

Summary

InnateDB Gene

IDBG-57611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW11

Gene Name

F-box and WD repeat domain containing 11

Synonyms

BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos

Species

Homo sapiens

Ensembl Gene

ENSG00000072803

Encoded Proteins

IDBP-57613

F-box and WD repeat domain containing 11

IDBP-57615

F-box and WD repeat domain containing 11

IDBP-242872

F-box and WD repeat domain containing 11

IDBP-476030

F-box and WD repeat domain containing 11

IDBP-479399

F-box and WD repeat domain containing 11

IDBP-474885

F-box and WD repeat domain containing 11

IDBP-474509

F-box and WD repeat domain containing 11

IDBP-474874

F-box and WD repeat domain containing 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:171861549-172006873

Strand

Reverse strand

Band

q35.1

Transcripts

ENST00000265094	ENSP00000265094
ENST00000296933	ENSP00000296933
ENST00000393802	ENSP00000377391
ENST00000523843	ENSP00000430104
ENST00000518106
ENST00000522376
ENST00000522891
ENST00000519693	ENSP00000427777
ENST00000517395	ENSP00000428753
ENST00000520376	ENSP00000431100
ENST00000518752	ENSP00000429818
ENST00000522507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0042753	positive regulation of circadian rhythm
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048511	rhythmic process