InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VASP

Summary

InnateDB Gene

IDBG-57716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VASP

Gene Name

vasodilator-stimulated phosphoprotein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000125753

Encoded Proteins

IDBP-57718

vasodilator-stimulated phosphoprotein

IDBP-765037

IDBP-765297

IDBP-761544

IDBP-761406

IDBP-765190

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 14679200

VASP is an important component of the cellular microfilament system that plays a major role in the regulation of serum response element (SRE)-dependent transcription. VASP activity is regulated by GMP-dependent protein kinase (G-kinase).

Entrez Gene

Summary

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45506579-45526983

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000245932	ENSP00000245932
ENST00000590459
ENST00000589627	ENSP00000467061
ENST00000586014	ENSP00000467005
ENST00000590603	ENSP00000467773
ENST00000588463
ENST00000592139	ENSP00000464742
ENST00000586619
ENST00000588482	ENSP00000466319
ENST00000588273
ENST00000587444

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	78 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0030036	actin cytoskeleton organization
GO:0030838	positive regulation of actin filament polymerization
GO:0034329	cell junction assembly
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0051289	protein homotetramerization

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0070062	extracellular vesicular exosome