Homo sapiens Gene: VASP
Summary
InnateDB Gene IDBG-57716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VASP
Gene Name vasodilator-stimulated phosphoprotein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125753
Encoded Proteins
vasodilator-stimulated phosphoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
VASP is an important component of the cellular microfilament system that plays a major role in the regulation of serum response element (SRE)-dependent transcription. VASP activity is regulated by GMP-dependent protein kinase (G-kinase).
Entrez Gene
Summary Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45506579-45526983
Strand Forward strand
Band q13.32
Transcripts
ENST00000245932 ENSP00000245932
ENST00000590459
ENST00000589627 ENSP00000467061
ENST00000586014 ENSP00000467005
ENST00000590603 ENSP00000467773
ENST00000588463
ENST00000592139 ENSP00000464742
ENST00000586619
ENST00000588482 ENSP00000466319
ENST00000588273
ENST00000587444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 78 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001843 neural tube closure
GO:0007411 axon guidance
GO:0008154 actin polymerization or depolymerization
GO:0030036 actin cytoskeleton organization
GO:0030838 positive regulation of actin filament polymerization
GO:0034329 cell junction assembly
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
BCR pathway
TSH pathway
TSLP pathway
REACTOME
Developmental Biology pathway
Cell-Cell communication pathway
TCR signaling pathway
Cell junction organization pathway
Axon guidance pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Robo receptor pathway
Generation of second messenger molecules pathway
Cell-extracellular matrix interactions pathway
KEGG
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
INOH
PID BIOCARTA
PID NCI
IL8- and CXCR2-mediated signaling events
PAR1-mediated thrombin signaling events
Stabilization and expansion of the E-cadherin adherens junction
E-cadherin signaling in keratinocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515469 Hs.739385
RefSeq NM_003370 XM_005259199 XM_005259200
HUGO
OMIM
CCDS CCDS33051
HPRD 03415
IMGT
EMBL
GenPept
RNA Seq Atlas