Homo sapiens Gene: MYH9
Summary
InnateDB Gene IDBG-5777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH9
Gene Name myosin, heavy chain 9, non-muscle
Synonyms BDPLT6; DFNA17; EPSTS; FTNS; MHA; NMHC-II-A; NMMHC-IIA; NMMHCA;
Species Homo sapiens
Ensembl Gene ENSG00000100345
Encoded Proteins
myosin, heavy chain 9, non-muscle
myosin, heavy chain 9, non-muscle
myosin, heavy chain 9, non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The calpain-MYH9-RAB7B axis regulates TLR4 containing alpha-granules trafficking in thrombin-stimulated platelets.
Entrez Gene
Summary This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36281281-36388018
Strand Reverse strand
Band q12.3
Transcripts
ENST00000216181 ENSP00000216181
ENST00000401701 ENSP00000384631
ENST00000456729 ENSP00000414852
ENST00000475726
ENST00000486218
ENST00000459960
ENST00000495928
ENST00000473022
ENST00000477189
ENST00000472210
ENST00000463027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 135 [view]
Protein-Protein 133 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003774 motor activity
GO:0003779 actin binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0030898 actin-dependent ATPase activity
GO:0042803 protein homodimerization activity
GO:0043495 protein anchor
GO:0043531 ADP binding
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000904 cell morphogenesis involved in differentiation
GO:0000910 cytokinesis
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001768 establishment of T cell polarity
GO:0006200 ATP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006509 membrane protein ectodomain proteolysis
GO:0006928 cellular component movement
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007520 myoblast fusion
GO:0008152 metabolic process
GO:0008360 regulation of cell shape
GO:0015031 protein transport
GO:0016337 single organismal cell-cell adhesion
GO:0030048 actin filament-based movement
GO:0030220 platelet formation
GO:0030224 monocyte differentiation
GO:0031032 actomyosin structure organization
GO:0031532 actin cytoskeleton reorganization
GO:0032796 uropod organization
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043534 blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0050900 leukocyte migration
GO:0051295 establishment of meiotic spindle localization
Cellular Component
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0001772 immunological synapse
GO:0001931 uropod
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005826 actomyosin contractile ring
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0005938 cell cortex
GO:0008180 COP9 signalosome
GO:0008305 integrin complex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030863 cortical cytoskeleton
GO:0031252 cell leading edge
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0042641 actomyosin
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0097513 myosin II filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Sema4D in semaphorin signaling pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Semaphorin interactions pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
EPHA-mediated growth cone collapse pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Tight junction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.474751 Hs.713174 Hs.735360
RefSeq NM_002473
HUGO
OMIM
CCDS CCDS13927
HPRD 01177
IMGT
EMBL
GenPept
RNA Seq Atlas