Homo sapiens Gene: CFL1
Summary
InnateDB Gene IDBG-57818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFL1
Gene Name cofilin 1 (non-muscle)
Synonyms CFL; HEL-S-15;
Species Homo sapiens
Ensembl Gene ENSG00000172757
Encoded Proteins
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
cofilin 1 (non-muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65823022-65862026
Strand Reverse strand
Band q13.1
Transcripts
ENST00000308162 ENSP00000309629
ENST00000530157
ENST00000527752
ENST00000525710
ENST00000525451 ENSP00000432660
ENST00000530945
ENST00000527344 ENSP00000432155
ENST00000531407 ENSP00000433910
ENST00000524553 ENSP00000432226
ENST00000534769 ENSP00000431696
ENST00000531413 ENSP00000433131
ENST00000532134 ENSP00000436431
ENST00000530413 ENSP00000436899
ENST00000534784 ENSP00000433308
ENST00000526975 ENSP00000432153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 92 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001755 neural crest cell migration
GO:0001842 neural fold formation
GO:0002576 platelet degranulation
GO:0006468 protein phosphorylation
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0009615 response to virus
GO:0022604 regulation of cell morphogenesis
GO:0030010 establishment of cell polarity
GO:0030036 actin cytoskeleton organization
GO:0030042 actin filament depolymerization
GO:0030168 platelet activation
GO:0030836 positive regulation of actin filament depolymerization
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0045087 innate immune response
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030864 cortical actin cytoskeleton
GO:0031258 lamellipodium membrane
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TNFalpha pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Sema3A PAK dependent Axon repulsion pathway
Immune System pathway
Response to elevated platelet cytosolic Ca2+ pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
Hemostasis pathway
KEGG
Axon guidance pathway
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Ccr3 signaling in eosinophils [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
PID NCI
CXCR4-mediated signaling events
RAC1 signaling pathway
CDC42 signaling events
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.121449 Hs.738283
RefSeq NM_005507
HUGO
OMIM
CCDS CCDS8114
HPRD 03261
IMGT
EMBL
GenPept
RNA Seq Atlas