Homo sapiens Gene: NCK1
Summary
InnateDB Gene IDBG-58017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCK1
Gene Name NCK adaptor protein 1
Synonyms NCK; nck-1; NCKalpha;
Species Homo sapiens
Ensembl Gene ENSG00000158092
Encoded Proteins
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
NCK adaptor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:136862208-136949823
Strand Forward strand
Band q22.3
Transcripts
ENST00000288986 ENSP00000288986
ENST00000481752 ENSP00000417273
ENST00000491539 ENSP00000419302
ENST00000485096 ENSP00000419677
ENST00000476286 ENSP00000418513
ENST00000460960
ENST00000478862
ENST00000488930 ENSP00000417729
ENST00000496489 ENSP00000419544
ENST00000469404 ENSP00000419631
ENST00000467911 ENSP00000418060
ENST00000482071
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 142 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 142 [view]
Protein-Protein 141 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
GO:0030159 receptor signaling complex scaffold activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006417 regulation of translation
GO:0006469 negative regulation of protein kinase activity
GO:0007015 actin filament organization
GO:0007172 signal complex assembly
GO:0007411 axon guidance
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030838 positive regulation of actin filament polymerization
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045087 innate immune response
GO:0045859 regulation of protein kinase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050852 T cell receptor signaling pathway
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0012506 vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
BCR pathway
Prolactin pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Cell-Cell communication pathway
TCR signaling pathway
Nephrin interactions pathway
Signaling by VEGF pathway
Innate Immune System pathway
Axon guidance pathway
Activation of Rac pathway
Signal Transduction pathway
Netrin-1 signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
VEGFA-VEGFR2 Pathway pathway
DCC mediated attractive signaling pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signaling by Robo receptor pathway
Signaling by PDGF pathway
Generation of second messenger molecules pathway
Signaling by the B Cell Receptor (BCR) pathway
KEGG
ErbB signaling pathway pathway
Axon guidance pathway
T cell receptor signaling pathway pathway
Pathogenic Escherichia coli infection pathway
INOH
PDGF signaling pathway pathway
PID BIOCARTA
Y branching of actin filaments [Biocarta view]
PID NCI
Netrin-mediated signaling events
TCR signaling in na´ve CD4+ T cells
EPHB forward signaling
Angiopoietin receptor Tie2-mediated signaling
Signaling events regulated by Ret tyrosine kinase
VEGFR1 specific signals
Stabilization and expansion of the E-cadherin adherens junction
Arf6 signaling events
Insulin Pathway
Cross-References
SwissProt P16333
TrEMBL C9J0K5 C9J869 C9JAB9 C9JVV5 C9K098
UniProt Splice Variant
Entrez Gene 4690
UniGene Hs.477693 Hs.627323
RefSeq NM_001190796 NM_001291999 NM_006153 XM_006713650 XM_006713651 XM_006713652
HUGO HGNC:7664
OMIM 600508
CCDS CCDS3092 CCDS54644
HPRD
IMGT
EMBL AC011597 AK301460 BC006403 CH471052 X17576
GenPept AAH06403 BAH13487 CAA35599 EAW79105 EAW79108 EAW79109
RNA Seq Atlas 4690