InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CUBN

Summary

InnateDB Gene

IDBG-58020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUBN

Gene Name

cubilin (intrinsic factor-cobalamin receptor)

Synonyms

gp280; IFCR; MGA1

Species

Homo sapiens

Ensembl Gene

ENSG00000107611

Encoded Proteins

IDBP-58022

cubilin (intrinsic factor-cobalamin receptor)

IDBP-58024

cubilin (intrinsic factor-cobalamin receptor)

IDBP-367702

cubilin (intrinsic factor-cobalamin receptor)

IDBP-367706

cubilin (intrinsic factor-cobalamin receptor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:16823964-17129831

Strand

Reverse strand

Band

p13

Transcripts

ENST00000377833	ENSP00000367064
ENST00000377823	ENSP00000367054
ENST00000438254	ENSP00000391830
ENST00000433666	ENSP00000415970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031419	cobalamin binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001894	tissue homeostasis
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0009235	cobalamin metabolic process
GO:0015889	cobalamin transport
GO:0042157	lipoprotein metabolic process
GO:0042359	vitamin D metabolic process
GO:0042953	lipoprotein transport
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0005905	coated pit
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0031232	extrinsic component of external side of plasma membrane
GO:0031526	brush border membrane
GO:0043202	lysosomal lumen
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome