Version 5.4
Homo sapiens Gene: FOSL1
Summary
InnateDB Gene IDBG-58044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOSL1
Gene Name FOS-like antigen 1
Synonyms FRA; fra-1; FRA1
Species Homo sapiens
Ensembl Gene ENSG00000175592
Encoded Proteins
IDBP-58046
FOS-like antigen 1
IDBP-378745
FOS-like antigen 1
IDBP-595236
FOS-like antigen 1
IDBP-588897
FOS-like antigen 1
IDBP-604073
FOS-like antigen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2008]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65892049-65900573
Strand Reverse strand
Band q13.1
Transcripts
ENST00000312562 ENSP00000310170
ENST00000448083 ENSP00000393302
ENST00000531493 ENSP00000436276
ENST00000532401 ENSP00000431594
ENST00000534222 ENSP00000434350
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
Experimentally validated
Total 51 [view]
Protein-Protein 39 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006935 chemotaxis
GO:0006968 cellular defense response
GO:0007296 vitellogenesis
GO:0007565 female pregnancy
GO:0007612 learning
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0009629 response to gravity
GO:0014070 response to organic cyclic compound
GO:0031668 cellular response to extracellular stimulus
GO:0032570 response to progesterone
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0045787 positive regulation of cell cycle
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0060674 placenta blood vessel development
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024912
View Gene Order
ENSBTAG00000006194
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
myc_activpathway
Validated targets of C-MYC transcriptional activation
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8061
UniGene Hs.283565
RefSeq NM_001300844 NM_001300855 NM_001300857 NM_005438 XM_005274311
HUGO HGNC:13718
OMIM 136515
CCDS CCDS73324 CCDS8121
HPRD 00643
IMGT
EMBL
GenPept
RNA Seq Atlas 8061

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca