InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VIM

Summary

InnateDB Gene

IDBG-58574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIM

Gene Name

vimentin

Synonyms

CTRCT30; HEL113

Species

Homo sapiens

Ensembl Gene

ENSG00000026025

Encoded Proteins

IDBP-58578

vimentin

IDBP-368075

vimentin

IDBP-583445

vimentin

IDBP-586638

vimentin

IDBP-583426

vimentin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:17228259-17237593

Strand

Forward strand

Band

p13

Transcripts

ENST00000224237	ENSP00000224237
ENST00000421459	ENSP00000391842
ENST00000478317
ENST00000478746
ENST00000497849
ENST00000487938	ENSP00000435613
ENST00000485947
ENST00000469543	ENSP00000431702
ENST00000495528
ENST00000544301	ENSP00000446007

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 278 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	278 [view]
Protein-Protein	276 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042802	identical protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006928	cellular component movement
GO:0010628	positive regulation of gene expression
GO:0010977	negative regulation of neuron projection development
GO:0014002	astrocyte development
GO:0016032	viral process
GO:0030049	muscle filament sliding
GO:0045103	intermediate filament-based process
GO:0045109	intermediate filament organization
GO:0060020	Bergmann glial cell differentiation
GO:0070307	lens fiber cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0031252	cell leading edge
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome