Version 5.4
Homo sapiens Gene: MAT2A
Summary
InnateDB Gene IDBG-59132.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAT2A
Gene Name methionine adenosyltransferase II, alpha
Synonyms MATA2; MATII; SAMS2
Species Homo sapiens
Ensembl Gene ENSG00000168906
Encoded Proteins
IDBP-59134
methionine adenosyltransferase II, alpha
IDBP-295348
methionine adenosyltransferase II, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85539165-85545280
Strand Forward strand
Band p11.2
Transcripts
ENST00000306434 ENSP00000303147
ENST00000409017 ENSP00000386353
ENST00000465151
ENST00000469221
ENST00000481412
ENST00000490878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 23 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004478 methionine adenosyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0006805 xenobiotic metabolic process
GO:0032259 methylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0048269 methionine adenosyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053907
View Gene Order
ENSBTAG00000020873
Not yet available
Pathways
NETPATH
REACTOME
REACT_6946
Methylation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Methionine Cysteine metabolism pathway
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL B4DN45
UniProt Splice Variant
Entrez Gene 4144
UniGene Hs.516157 Hs.605622 Hs.735294
RefSeq NM_005911
HUGO HGNC:6904
OMIM 601468
CCDS CCDS1977
HPRD 03275
IMGT
EMBL AC016753 AK297758 AK316411
GenPept BAG60107 BAH14782
RNA Seq Atlas 4144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca