Homo sapiens Gene: F13A1
Summary
InnateDB Gene IDBG-59186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F13A1
Gene Name coagulation factor XIII, A1 polypeptide
Synonyms F13A;
Species Homo sapiens
Ensembl Gene ENSG00000124491
Encoded Proteins
coagulation factor XIII, A1 polypeptide
coagulation factor XIII, A1 polypeptide
coagulation factor XIII, A1 polypeptide
coagulation factor XIII, A1 polypeptide
coagulation factor XIII, A1 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:6144085-6321013
Strand Reverse strand
Band p25.1
Transcripts
ENST00000264870 ENSP00000264870
ENST00000445223 ENSP00000394693
ENST00000414279 ENSP00000413334
ENST00000431222 ENSP00000416295
ENST00000451619 ENSP00000411114
ENST00000479211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0018149 peptide cross-linking
GO:0030168 platelet activation
Cellular Component
GO:0005576 extracellular region
GO:0031093 platelet alpha granule lumen
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Common Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL Q9NQP5
UniProt Splice Variant
Entrez Gene 2162
UniGene Hs.335513 Hs.713857
RefSeq NM_000129 XM_006715010
HUGO HGNC:3531
OMIM 134570
CCDS CCDS4496
HPRD 00604
IMGT
EMBL AL133326 AL157775 AL391420
GenPept
RNA Seq Atlas 2162