InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SFTPB

Summary

InnateDB Gene

IDBG-59448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFTPB

Gene Name

surfactant protein B

Synonyms

PSP-B; SFTB3; SFTP3; SMDP1; SP-B

Species

Homo sapiens

Ensembl Gene

ENSG00000168878

Encoded Proteins

IDBP-242847

surfactant protein B

IDBP-295372

surfactant protein B

IDBP-381788

surfactant protein B

IDBP-481960

surfactant protein B

IDBP-806426

surfactant protein B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90%% lipids and 10%% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:85657314-85668741

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000393822	ENSP00000377409
ENST00000409383	ENSP00000386346
ENST00000428225	ENSP00000415347
ENST00000519937	ENSP00000428719
ENST00000494165	ENSP00000476194
ENST00000491167
ENST00000473692

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006629	lipid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0007585	respiratory gaseous exchange
GO:0009887	organ morphogenesis

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000056370

View Gene Order

ENSBTAG00000021230

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.512690 Hs.593933

RefSeq

NM_000542 NM_198843 XM_005264487 XM_005264488 XM_005264489 XM_006712076

HUGO

OMIM

CCDS

CCDS1983

HPRD

01523

IMGT

EMBL

GenPept

RNA Seq Atlas