InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NOS1

Summary

InnateDB Gene

IDBG-59491.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS1

Gene Name

nitric oxide synthase 1 (neuronal)

Synonyms

bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS

Species

Homo sapiens

Ensembl Gene

ENSG00000089250

Encoded Proteins

IDBP-59493

nitric oxide synthase 1 (neuronal)

IDBP-59495

nitric oxide synthase 1 (neuronal)

IDBP-59497

nitric oxide synthase 1 (neuronal)

IDBP-812180

nitric oxide synthase 1 (neuronal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5\' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:117208142-117452170

Strand

Reverse strand

Band

q24.22

Transcripts

ENST00000317775	ENSP00000320758
ENST00000338101	ENSP00000337459
ENST00000344089	ENSP00000339862
ENST00000477584
ENST00000549189
ENST00000618760	ENSP00000477999

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0017080	sodium channel regulator activity
GO:0020037	heme binding
GO:0034617	tetrahydrobiopterin binding
GO:0034618	arginine binding
GO:0044325	ion channel binding
GO:0046870	cadmium ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding
GO:0097110	scaffold protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0002028	regulation of sodium ion transport
GO:0006527	arginine catabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0006941	striated muscle contraction
GO:0007263	nitric oxide mediated signal transduction
GO:0007520	myoblast fusion
GO:0007596	blood coagulation
GO:0009408	response to heat
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0031284	positive regulation of guanylate cyclase activity
GO:0033555	multicellular organismal response to stress
GO:0042136	neurotransmitter biosynthetic process
GO:0042738	exogenous drug catabolic process
GO:0043267	negative regulation of potassium ion transport
GO:0045776	negative regulation of blood pressure
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051346	negative regulation of hydrolase activity
GO:0051701	interaction with host
GO:0051926	negative regulation of calcium ion transport
GO:0055114	oxidation-reduction process
GO:0055117	regulation of cardiac muscle contraction
GO:0090382	phagosome maturation
GO:1902307	positive regulation of sodium ion transmembrane transport

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016529	sarcoplasmic reticulum
GO:0042383	sarcolemma
GO:0043197	dendritic spine
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029361

View Gene Order

ENSBTAG00000002023

Not yet available

Pathways

NETPATH

REACTOME

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_121256

Phagosomal maturation (early endosomal stage) pathway

REACT_121237

Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway

REACT_116125

Disease pathway

REACT_604

Hemostasis pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

hsa05010

Alzheimer's disease pathway

hsa04730

Long-term depression pathway

hsa04020

Calcium signaling pathway pathway

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

hsa04970

Salivary secretion pathway

hsa04145

Phagosome pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.735734

RefSeq

NM_000620 NM_001204213 NM_001204214 NM_001204218 XM_006719426 XM_006719427 XM_006719428

HUGO

OMIM

CCDS

CCDS41842 CCDS55890

HPRD

01226

IMGT

EMBL

GenPept

RNA Seq Atlas